CHANGES IN SKELETAL-MUSCLE OXYGENATION DURING INCREMENTAL EXERCISE MEASURED WITH NEAR-INFRARED SPECTROSCOPY

被引：190

作者：

BELARDINELLI, R ^{[1
]}

BARSTOW, TJ ^{[1
]}

PORSZASZ, J ^{[1
]}

WASSERMAN, K ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,HARBOR MED CTR,ST JOHNS CARDIOVASC CTR,DEPT MED,TORRANCE,CA 90509

来源：

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY | 1995年 / 70卷 / 06期

关键词：

HEMOGLOBIN; MYOGLOBIN; SATURATION; SKELETAL MUSCLE;

D O I：

10.1007/BF00634377

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

To determine the change in muscle oxygenation in response to progressively increasing work rate exercise, muscle oxyhemoglobin + oxymyoglobin saturation was measured transcutaneously with near infrared spectroscopy in the vastus lateralis muscle during cycle ergometry. Studies were done in 11 subjects while gas exchange was measured breath-by-breath. As work rate was increased, tissue oxygenation initially either remained constant near resting levels or, more usually, decreased. Near the work rate and metabolic rate where significant lactic acidosis was detected by excess CO2 production (lactic acidosis threshold, LAT), muscle oxygenation decreased more steeply. As maximum oxygen uptake (VO2max) was approached, the rate of desaturation slowed. In and of the 11 subjects, tissue O-2 saturation reached a minimum which was sustained for 1-3 min before VO2max was reached. The LAT correlated with both the VO2 (r = 0.95, P < 0.0001) and the work rate (r = 0.94, P < 0.0001) at which the rate of tissue O-2 desaturation accelerated. These results describe a consistent pattern in the rate of decrease in muscle oxygenation, slowly decreasing over the lower work rate range, decreasing more rapidly in the work rate range of the LAT and then slowing at about 80% of VO2max, approaching or reaching a minimum saturation at VO2max.

引用

页码：487 / 492

页数：6

共 14 条

[1]

Beaver W.L., Wasserman K., Whipp B.J., On-line computer analysis and breath-by-breath graphical display of exercise function tests, J Appl Physiol, 34, pp. 128-132, (1973)

[2]

Beaver W.L., Wasserman K., Whipp B.J., A new method for detecting anaerobic threshold by gas exchange, J Appl Physiol, 60, pp. 2020-2027, (1986)

[3]

Chance B., Jobsis F., Changes in fluorescence in a frog sartorius muscle following a twitch, Nature, 184, pp. 195-196, (1959)

[4]

Chance B., Weber A., The steady state of cytochrome b during rest and after contraction in frog sartorius, J Physiol (Lond), 169, pp. 263-277, (1963)

[5]

Chance B., Dait M.T., Zang C., Hamaoka T., Hagerman F., Recovery from exercise-induced desaturation in the quadriceps muscles of elite competitive rowers, Am J Physiol, 262, (1992)

[6]

Hampson N.B., Piantadosi C.A., Near infrared monitoring of human skeletal muscle oxygenation during forearm ischemia, J Appl Physiol, 64, pp. 2449-2457, (1988)

[7]

Jobsis F.F., Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters, Science, 198, pp. 1264-1267, (1977)

[8]

Jobsis-Vander Vliet F.F., Non-invasive, near infrared monitoring of cellular oxygen sufficiency in vivo, Oxygen transport to tissues, pp. 833-842, (1985)

[9]

Koike A., Wasserman K., McKenzie K.D., Zanconato S., Weiler-Ravell D., Evidence that diffusion limitation determines O<sub>2</sub> uptake kinetics during exercise in man, J Clin Invest, 86, pp. 1698-1706, (1990)

[10]

Millikan G.A., Experiments on muscle haemoglobin in vivo: the instantaneous measurement of muscle metabolism, Proc Soc Lond [Biol], 123, pp. 218-241, (1937)

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