ENANTIOSELECTIVE CATALYSIS .98. PREPARATION OF 9-AMINO(9-DEOXY)CINCHONA ALKALOIDS

被引：108

作者：

BRUNNER, H ^{[1
]}

BUGLER, J ^{[1
]}

NUBER, B ^{[1
]}

机构：

[1] UNIV HEIDELBERG,INST ANORGAN CHEM,D-69120 HEIDELBERG,GERMANY

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 07期

关键词：

D O I：

10.1016/0957-4166(95)00215-B

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Cinchonine and quinine were allowed to react with hydrazoic acid in a Mitsunobu reaction to yield the corresponding azides with inversion of configuration at C9. In situ reduction of these azides provided 9-amino(9-deoxy)epicinchonine and 9-amino(9-deoxy)epiquinine, respectively. The structures were confirmed by CD-spectroscopy and X-ray crystallography.

引用

页码：1699 / 1702

页数：4

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