TISSUE PENETRATION AND PULMONARY DISPOSITION OF TOBRAMYCIN

被引：20

作者：

MAZZEI, T

NOVELLI, A

DELALLA, F

MINI, E

PERITI, P

机构：

[1] Dipartimento di Farmacologia, Università degli Studi di Firenze

[2] Divisione di Malattie Infettive, Ospedale Civile S. Bortolo, Vicenza

来源：

JOURNAL OF CHEMOTHERAPY | 1995年 / 7卷 / 04期

关键词：

TOBRAMYCIN; SUCTION BLISTER FLUID; BRONCHOALVEOLAR LAVAGE; RESPIRATORY TRACT INFECTION;

D O I：

10.1179/joc.1995.7.4.363

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The pharmacokinetics of tobramycin, including the penetration into suction blister fluid (SBF), has been investigated in 12 patients with a mean age of 69.8 +/- 4.6 yrs, after a single i,m. administration of either 150 or 300 mg. Tobramycin demonstrated a concentration-independent pharmacokinetics and a high diffusion into the extravascular compartment with a penetration index (obtained by the SBF and serum AUC ratio) of 135% with no significant differences between the two groups of patients. Tobramycin was also administered as a single or multiple i.m. dose of 300 mg in 10 intensive care patients undergoing fiberoptic bronchoscopy for diagnostic purposes. The aminoglycoside mean concentration 6 h after the single or last administration ranged from 5.3 to 5.5 mg/l and from 3.0 to 3.3 mg/l in alveolar lining fluid (ALF) and macrophages (AM), respectively, thus demonstrating that the once-daily dosage schedule leads to high and persistent levels in the bronchial alveolar tree, exceeding the minimum inhibitory concentrations in vitro for susceptible respiratory pathogens.

引用

页码：363 / 370

页数：8

共 24 条

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