CONJUGATION OF 1-NAPHTHOL IN THE GASTRIC-MUCOSA OF GUINEA-PIGS

被引：8

作者：

SCHWENK, M ^{[1
]}

LINZ, C ^{[1
]}

KOBUSCH, AB ^{[1
]}

机构：

[1] UNIV TUBINGEN,TOXIKOL,W-7400 TUBINGEN 1,GERMANY

来源：

BIOCHEMICAL PHARMACOLOGY | 1991年 / 42卷 / 03期

关键词：

D O I：

10.1016/0006-2952(91)90307-Q

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1-Naphthol was conjugated in tissue pieces of the gastric wall to naphthol glucuronide (85%) and naphthol sulfate (15%). There was no regioselectivity in different parts of the stomach. In separated gastric mucosal cell populations, the activities of both transferases were highest in the mucous cell fraction (apparent V(max) of glucuronidation: 0.83 nmol/mg protein/min; apparent V(max) of sulfation: 0.11) with only little, or no activity in chief cells and parietal cells. Immunohistochemically glucuronosyltransferase 1 was predominantly localized in surface mucous cells. In conclusion, the gastric mucosa is an important organ for phase II biotransformation.

引用

页码：469 / 473

页数：5

共 14 条

[1]

AITIO A, 1975, EXPT ULCER, V2, P17

[2] PROPERTIES OF A 3-METHYLCHOLANTHRENE-INDUCIBLE PHENOL UDP-GLUCURONOSYLTRANSFERASE FROM RAT-LIVER [J].