THE OVINE BOOROOLA FECUNDITY GENE (FECB) IS LINKED TO MARKERS FROM A REGION OF HUMAN CHROMOSOME-4Q

被引：163

作者：

MONTGOMERY, GW ^{[1
]}

CRAWFORD, AM ^{[1
]}

PENTY, JM ^{[1
]}

DODDS, KG ^{[1
]}

EDE, AJ ^{[1
]}

HENRY, HM ^{[1
]}

PIERSON, CA ^{[1
]}

LORD, EA ^{[1
]}

GALLOWAY, SM ^{[1
]}

SCHMACK, AE ^{[1
]}

SISE, JA ^{[1
]}

SWARBRICK, PA ^{[1
]}

HANRAHAN, V ^{[1
]}

BUCHANAN, FC ^{[1
]}

HILL, DF ^{[1
]}

机构：

[1] UNIV OTAGO, CTR GENE RES, DUNEDIN, NEW ZEALAND

来源：

NATURE GENETICS | 1993年 / 4卷 / 04期

关键词：

D O I：

10.1038/ng0893-410

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The autosomal Booroola fecundity gene (FecB) mutation in sheep increases ovulation rate and litter size, with associated effects on ovarian physiology and hormone profiles. Analysis of segregation in twelve families (379 female progeny) identified linkage between the mutation, two microsatellite markers (OarAE101 and OarHH55, Z(max) >9.0) and epidermal growth factor (EGF) from human chromosome 4q25 (Z(max) >3.0). The marker OarAE101 was linked to secreted phosphoprotein 1 (SPP1, which maps to chromosome 4q21-23 in man) in the test pedigrees and independent families (Z(max) >9.7). The identification of linkage between the FecB mutation and markers from human chromosome 4q is an important step towards further understanding the control of ovulation rates in mammals.

引用

页码：410 / 414

页数：5

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