DO CHANGES IN CARDIOVASCULAR RISK-FACTORS EXPLAIN CHANGES IN MORTALITY FROM STROKE IN FINLAND

被引：78

作者：

VARTIAINEN, E

SARTI, C

TUOMILEHTO, J

KUULASMAA, K

机构：

[1] Department of Epidemiology and Health Promotion, National Public Health Institute Mannerheimintie 166, Helsinki

来源：

BMJ-BRITISH MEDICAL JOURNAL | 1995年 / 310卷 / 6984期

关键词：

D O I：

10.1136/bmj.310.6984.901

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives-To estimate the extent to which the changes in the main cardiovascular risk factors (blood pressure, smoking, and serum cholesterol concentration) can explain the observed changes in mortality from stroke in Finland during the past 20 years. Design-Predicted changes in mortality from cerebrovascular disease mortality were calculated by a proportional hazards model from data obtained in cross sectional population surveys in 1972, 1977, 1982, 1987, and 1992. Predicted changes were compared with the observed changes in mortality statistics. Setting-North Karelia and Kuopio provinces, Finland. Subjects-16 741 men and 16 389 women aged 30-59 randomly selected from the national population register, of whom 14 054 men and 14 546 women participated. Main outcome measures-levels of risk factors and predicted and observed changes in mortality from cerebrovascular disease. Results-The observed changes in diastolic blood pressure, total serum cholesterol concentration, and smoking in the population from 1972 to 1992 predicted a 44% fall in mortality from stroke in men and changes in diastolic blood pressure and smoking predicted a 34% fall in women. The observed fall in mortality from stroke was 66% in men and 60% in women. Conclusions-Two thirds of the fall in mortality hom stroke in men and half in women can be explained by changes in the three main cardiovascular risk factors.

引用

页码：901 / 904

页数：4

共 24 条

[1]

Bonita R., Stewart A., Beaglehole R., International trends in stroke mortality: 1970–85, Stroke, 21, pp. 989-992, (1990)

[2]

Ueshima H., Iida M., Shimamoto T., Konishi K., Tanagaki M., Nakanishi N., Et al., Multivariate analysis of risk factors for stroke. Eight-year follow-up of farming villages in Akita, Japan, Prev Med, 9, pp. 722-740, (1980)

[3]

Kagan A., Popper J.S., Rhoads G.G., Factors related to stroke incidence in Hawaii Japanese men, Stroke, 11, pp. 14-20, (1980)

[4]

Tanaka H., Ueda Y., Hayashi M., Date C., Baba T., Yamashita H., Et al., Risk factors for cerebral hemorrhage and cerebral infarction in a Japanese rural community, Stroke, 13, pp. 62-73, (1982)

[5]

Stokes J., Kannel W.B., Wolf P.A., D'Agostino R.B., Cupples L.A., Blood pressure as a risk factor for cardiovascular disease: the Framingham study–30 years of follow-up, Hypertens, 13, pp. 113-118, (1989)

[6]

Menotti A., Keys A., Blackburn H., Aravanis C., Dontas A., Fidanza F., Et al., Twenty-year stroke mortality and prediction in twelve cohorts of the seven countries study, Int J Epidemiol, 19, pp. 309-315, (1990)

[7]

Collins R., Peto R., MacMahon S., Hebert P., Fiebach N.H., Eberlein K.A., Et al., Blood pressure, stroke, and coronary heart disease. II. Short-term reductions in blood pressure: overview of randomized drug trials in their epidemiological context, Lancet, 335, pp. 827-838, (1990)

[8]

MacMahon S., Peto R., Cutler J., Collins R., Sorlie P., Neaton J., Et al., Blood pressure, stroke, and coronary heart disease. I. Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias, Lancet, 335, pp. 765-774, (1990)

[9]

Shinton R., Beevers G., Meta-analysis of relation between cigarette smoking and stroke, BMJ, 298, pp. 787-794, (1989)

[10]

Yano K., Reed D.M., MacLean C., Serum cholesterol and hemorrhagic stroke in the Honolulu heart program, Stroke, 20, pp. 1460-1465, (1989)

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