REPETITIVE DNA IN AND AROUND TRANSLOCATION BREAKPOINTS OF THE PHILADELPHIA-CHROMOSOME

被引：13

作者：

TOTH, G ^{[1
]}

JURKA, J ^{[1
]}

机构：

[1] LINUS PAULING INST SCI & MED,440 PAGE MILL RD,PALO ALTO,CA 94306

来源：

GENE | 1994年 / 140卷 / 02期

关键词：

BREAKPOINT CLUSTER REGION; REPETITIVE SEQUENCE; ALU; MER; ACUTE LEUKEMIA;

D O I：

10.1016/0378-1119(94)90559-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

This paper describes systematic sequence studies of repetitive DNA in and around translocation breakpoints on chromosomes 9 and 22, which are involved in the formation of the Philadelphia chromosome in acute leukemias. In addition to Alu repeats described in previous studies, the breakpoint regions appear to contain many other repetitive elements, including a member of a new repetitive family (MER34) reported in this paper. Identification of these repeats broadens current studies on the possible involvement of repetitive DNA in this intensely studied chromosomal translocation.

引用

页码：285 / 288

页数：4

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