OSMOTIC SWELLING ACTIVATES INTERMEDIATE-CONDUCTANCE CL- CHANNELS IN HUMAN INTESTINAL EPITHELIAL-CELLS

被引：38

作者：

OKADA, Y

PETERSEN, CCH

KUBO, M

MORISHIMA, S

TOMINAGA, M

机构：

[1] Department of Cellular and Molecular Physiology, National Institute for Physiological Sciences, Okazaki

[2] AFRC Laboratory of Molecular Signalling, Department of Zoology, Cambridge University

来源：

JAPANESE JOURNAL OF PHYSIOLOGY | 1994年 / 44卷 / 04期

关键词：

CL-; CHANNEL; CELL VOLUME REGULATION; HUMAN EPITHELIAL CELL;

D O I：

10.2170/jjphysiol.44.403

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

During osmotic swelling of a human intestinal epithelial cell line, stepwise closing unitary events of Cl- channels could be observed in cell-attached patches upon application of large positive potentials only when inactivating whole-cell Cl- currents were simultaneously observed. The closing process became faster with increasing positive command pulses. The unitary conductance was around 32 pS at 60 mV, 37 pS at + 100 mV, and 47 pS at + 140 mV exhibiting outward rectification.

引用

页码：403 / 409

页数：7

共 19 条

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[2]

Cahalan M.D., 1988, CELL PHYSL BLOOD, P282

[3]

CHRISTENSEN O, 1992, J MEMBRANE BIOL, V129, P13

[4] ACTIVATION OF BASOLATERAL CL- CHANNELS IN THE RAT COLONIC EPITHELIUM DURING REGULATORY VOLUME DECREASE [J].