CRF FACILITATES NE RELEASE FROM THE HIPPOCAMPUS - A MICRODIALYSIS STUDY

被引：30

作者：

LEE, EHY

CHANG, SY

CHEN, AYJ

机构：

[1] Institute of Biomedical Sciences, Academia Sinica, Taipei

来源：

NEUROSCIENCE RESEARCH | 1994年 / 19卷 / 03期

关键词：

CORTICOTROPIN-RELEASING FACTOR; NOREPINEPHRINE; DENTATE GYRUS; MICRODIALYSIS; LOCOMOTOR ACTIVITY;

D O I：

10.1016/0168-0102(94)90045-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using the in vivo microdialysis method, we have found that at moderate doses (1.44, 3.6 and 7.2 mu g), corticotropin-releasing factor (CRF) facilitated norepinephrine (NE) release from the dentate gyrus of hippocampus in rats in a dose-response fashion. The same doses of CRF also enhanced locomotor activity in rats. On the other hand, CRF at the highest dose studied (14.4 mu g) decreased NE release as well as locomotor activity in rats. These neuropeptide/neurotransmitter interactions may have significant physiological implications.

引用

页码：327 / 330

页数：4

共 18 条

[1] CHARACTERIZATION OF HIPPOCAMPAL NOREPINEPHRINE RELEASE AS MEASURED BY MICRODIALYSIS PERFUSION - PHARMACOLOGICAL AND BEHAVIORAL-STUDIES
ABERCROMBIE, ED
KELLER, RW
ZIGMOND, MJ
[J]. NEUROSCIENCE, 1988, 27 (03) : 897 - 904
[2] [Anonymous], 1971, STAT PRINCIPLES EXPT
[3] NORADRENERGIC MEDIATION OF THE MEMORY-ENHANCING EFFECT OF CORTICOTROPIN-RELEASING FACTOR IN THE LOCUS-CERULEUS OF RATS
CHEN, MF
CHIU, TH
LEE, EHY
[J]. PSYCHONEUROENDOCRINOLOGY, 1992, 17 (2-3) : 113 - 124
[4] EXCITATORY AMINO-ACIDS IN THE BRAIN - FOCUS ON NMDA RECEPTORS
COTMAN, CW
IVERSEN, LL
[J]. TRENDS IN NEUROSCIENCES, 1987, 10 (07) : 263 - 265
[5] CONDITIONED FEAR AND STARTLE MAGNITUDE - EFFECTS OF DIFFERENT FOOTSHOCK OR BACKSHOCK INTENSITIES USED IN TRAINING
DAVIS, M
ASTRACHAN, DI
[J]. JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES, 1978, 4 (02): : 95 - 103
[6] DESOUZA EB, 1987, J NEUROSCI, V7, P88
[7] CORTICOTROPIN-RELEASING FACTOR ACTIVATES THE NORADRENERGIC NEURON SYSTEM IN THE RAT-BRAIN
EMOTO, H
TANAKA, M
KOGA, C
YOKOO, H
TSUDA, A
YOSHIDA, M
[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1993, 45 (02) : 419 - 422
[8] INTROINICOLLISO.IB, 1989, BRAIN RES, V245, P1385
[9] ROLE OF NMDA RECEPTORS IN MEMORY
IZQUIERDO, I
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (04) : 128 - 129
[10] PROTEIN-SYNTHESIS IN THE HIPPOCAMPUS ASSOCIATED WITH MEMORY FACILITATION BY CORTICOTROPIN-RELEASING FACTOR IN RATS
LEE, EHY
HUNG, HC
LU, KT
CHEN, WH
CHEN, HY
[J]. PEPTIDES, 1992, 13 (05) : 927 - 937

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