PREVENTION OF DELAYED VASOSPASM BY AN ENDOTHELIN ET(A) RECEPTOR ANTAGONIST, BQ-123 - CHANGE OF ET(A) RECEPTOR MESSENGER-RNA EXPRESSION IN A CANINE SUBARACHNOID HEMORRHAGE MODEL

被引：77

作者：

ITOH, S

SASAKI, T

ASAI, A

KUCHINO, Y

机构：

[1] UNIV TOKYO, FAC MED, DEPT NEUROSURG, TOKYO 113, JAPAN

[2] NATL CANC CTR, RES INST, TOKYO 104, JAPAN

来源：

JOURNAL OF NEUROSURGERY | 1994年 / 81卷 / 05期

关键词：

CEREBRAL VASOSPASM; ENDOTHELIN RECEPTOR; SUBARACHNOID HEMORRHAGE; BQ-123; DOG;

D O I：

10.3171/jns.1994.81.5.0759

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors investigated the roles of endothelin (ET)-1 and the ET,receptor in the pathogenesis of delayed cerebral vasospasm following subarachnoid hemorrhage (SAH). A study was made of the preventive effect of a novel ET(A) receptor antagonist, BQ-123, on vasospasm and the expression of the ET(A) receptor messenger ribonucleic acid (mRNA) using a canine two-hemorrhage SAH model. Continuous intrathecal administration of BQ-123 (5 x 10(-6) mol/day) prevented narrowing of the basilar artery on Day 7 after SAH in 97.6% of cases in the study group versus 70.7% of cases in the control group (p < 0.05). While expression of the mRNA-coding ET(A) receptor was not detected in the control animals, it markedly increased on Day 3 after SAH and was also detected on Day 7. The results suggest that endothelin-1 and the ET(A) receptor participate in the pathogenesis of delayed cerebral vasospasm following SAH.

引用

页码：759 / 764

页数：6

共 45 条

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