MONOAMINERGIC SYSTEMS ACTIVITY AND CELLULAR DEFENSE-MECHANISMS IN THE BRAIN-STEM OF YOUNG AND AGED RATS SUBCHRONICALLY EXPOSED TO MANGANESE

被引：6

作者：

DESOLE, MS ^{[1
]}

MIELE, M ^{[1
]}

ESPOSITO, G ^{[1
]}

MIGHELI, R ^{[1
]}

FRESU, L ^{[1
]}

ENRICO, P ^{[1
]}

DENATALE, G ^{[1
]}

MIELE, E ^{[1
]}

机构：

[1] UNIV SASSARI,INST PHARMACOL,I-07100 SASSARI,ITALY

来源：

NEUROSCIENCE LETTERS | 1994年 / 177卷 / 1-2期

关键词：

MANGANESE NEUROTOXICITY; OXIDATIVE STRESS; GSH; ASCORBIC ACID; URIC ACID; BRAIN-STEM; RAT;

D O I：

10.1016/0304-3940(94)90047-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In 3- and 20-month-old male Wistar rats, levels of noradrenaline (NA), dopamine (DA), 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), ascorbic acid (AA), dehydroascorbic acid (DHAA), uric acid and glutathione (GSH) were determined by HPLC in the brainstem after subchronic oral exposure to MnCl2 200 mg/kg (3-month-old) and 30-100-200 mg/kg (20-month-old). In aged rats, manganese (Mn) significantly decreased levels of NA, DA and GSH and increased 5-HIAA/5-HT ratio values and DHAA and uric acid levels. All these parameters were scarcely affected in young rats. In aged rats, individual total Mn doses/rat were inversely correlated with individual DA levels (r = -0.405) and GSH levels (r = -0.450). In conclusion, Mn induces changes in markers of monoaminergic systems activity in the brainstem of aged rats considerably greater than in young rats. The increase in AA oxidation and decrease in GSH levels are consistent with a Mn-induced increase in formation of reactive oxygen species. The increase in uric acid levels provides evidence that one of these species might arise from the activity of xanthine-oxidase on uric acid precursors.

引用

页码：71 / 74

页数：4

共 17 条

[1] OXYGEN FREE-RADICALS AND PARKINSONS-DISEASE [J].

ADAMS, JD ;

ODUNZE, IN .

FREE RADICAL BIOLOGY AND MEDICINE, 1991, 10 (02) :161-169

[2]

ANDERSON ME, 1985, METHOD ENZYMOL, V113, P348

[3] MPTP METABOLITES INHIBIT RAT-BRAIN GLUTATHIONE S-TRANSFERASES [J].

AWASTHI, YC ;

SINGH, SV ;

SHEN, RS ;

ABELL, CW ;

GESSNER, W ;

BROSSI, A .

NEUROSCIENCE LETTERS, 1987, 81 (1-2) :159-164

[4] EFFECTS OF AGING ON 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) NEUROTOXIC EFFECTS ON STRIATUM AND BRAIN-STEM IN THE RAT [J].

DESOLE, MS ;

ESPOSITO, G ;

ENRICO, P ;

MIELE, M ;

FRESU, L ;

DENATALE, G ;

MIELE, E ;

GRELLA, G .

NEUROSCIENCE LETTERS, 1993, 159 (1-2) :143-146

[5]

DESOLE MS, 1993, NEUROSCI LETT, V159, P121

[6]

DONALDSON J, 1987, NEUROTOXICOLOGY, V8, P451

[7] MN2+ SEQUESTRATION BY MITOCHONDRIA AND INHIBITION OF OXIDATIVE-PHOSPHORYLATION [J].

GAVIN, CE ;

GUNTER, KK ;

GUNTER, TE .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1992, 115 (01) :1-5

[8]

GRAHAM DG, 1984, NEUROTOXICOLOGY, V5, P113

[9]

LICCIONE JJ, 1988, J PHARMACOL EXP THER, V247, P156

[10]

LYDEN A, 1984, ACTA PHARMACOL TOX, V55, P133

← 1 2 →