BIOCHEMICAL BASIS FOR INCREASED SUSCEPTIBILITY TO CIDOFOVIR OF HERPES-SIMPLEX VIRUSES WITH ALTERED OR DEFICIENT THYMIDINE KINASE-ACTIVITY

被引:34
作者
MENDEL, DB
BARKHIMER, DB
CHEN, MS
机构
[1] Dept. of Biochemistry and Virology, Gilead Sciences, Foster City, CA 94404
关键词
D O I
10.1128/AAC.39.9.2120
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
It has been observed that herpes simplex virus mutants with deficient or altered thymidine kinase activity are more susceptible to Cidofovir {CDV; 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl] cytosine dihydrate} in tissue culture than are the parental strains. During infection of cells, the elevation of the dCTP pool by thymidine kinase mutant viruses is less than that induced by the wild-type virus. The competition between CDV diphosphate and dCTP at the viral polymerase is therefore changed in favor of CDV diphosphate, enhancing its activity.
引用
收藏
页码:2120 / 2122
页数:3
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