ACTIVATION OF C-MYC AND C-K-RAS ONCOGENES IN PRIMARY RAT-TUMORS INDUCED BY IONIZING-RADIATION

被引：95

作者：

SAWEY, MJ ^{[1
]}

HOOD, AT ^{[1
]}

BURNS, FJ ^{[1
]}

GARTE, SJ ^{[1
]}

机构：

[1] NYU, INST ENVIRONM MED, NEW YORK, NY 10016 USA

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1987年 / 7卷 / 02期

关键词：

D O I：

10.1128/MCB.7.2.932

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An activated K-ras oncogene was detected by transfection in NIH 3T3 cells and by Southern blot analysis in 6 of 12 rat skin tumors induced by ionizing radiation. The DNA from 10 of the 12 tumors also showed c-myc gene amplification and restriction polymorphisms. Evidence for tissue specificity was observed in patterns of oncogene activation, with each of three clear cell carcinomas exhibiting activation of both c-mycand K-ras oncogenes.

引用

页码：932 / 935

页数：4

共 38 条

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ALBERT RE, 1969, CANCER RES, V29, P658

[2]

[Anonymous], RAD CARCINOGENESIS

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