CNS CHANGES IN HYPER-BILITRUBINEMIA - FUNCTIONAL IMPLICATIONS

被引:49
作者
JEW, JY
SANDQUIST, D
机构
[1] Department of Anatomy, College of Medicine, University of Iowa, Iowa City
关键词
D O I
10.1001/archneur.1979.00500390067007
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Hyperbilirubinemia is a recognized etiologic factor in motor and hearing disorders associated with cerebral palsy. Its role in more subtle forms of neurological impairment is more controversial. Using a mutant animal model, which develops symptoms and signs closely resembling the human kernicterus syndrome, neurons of hippocampus, cerebral cortex, cochlear nuclei, locus ceruleus, and olfactory bulb were examined by electron microscopy. Pathological changes, observed in all areas studied, consisted of mitochondrial and endoplasmic enlargement and vacuolation, with glycogen deposition; increased extracellular space; myelin figures; and degenerating changes in nerve terminals. If we make the assumption that pathologic changes in the human infant with neonatal jaundice are similar to changes in the animal model, then the widespread involvement of CNS neurons in all cortical areas examined may well help to explain the syndromes of minimal cerebral dysfunction reported in clinical studies. © 1979, American Medical Association. All rights reserved.
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页码:149 / 154
页数:6
相关论文
共 53 条
[1]  
AGASSIZ CDS, 1949, LANCET, V257, P1030
[2]   LOCALIZATION OF GLYCOGEN IN SPERMATOZOA OF VARIOUS INVERTEBRATE AND VERTEBRATE SPECIES [J].
ANDERSON, WA ;
PERSONNE, P .
JOURNAL OF CELL BIOLOGY, 1970, 44 (01) :29-+
[3]   NOREPINEPHRINE-DOPAMINE INTERACTIONS AND BEHAVIOR [J].
ANTELMAN, SM ;
CAGGIULA, AR .
SCIENCE, 1977, 195 (4279) :646-653
[5]   ADULT-ONSET ACID MALTASE DEFICIENCY - MORPHOLOGIC AND BIOCHEMICAL ABNORMALITIES REPRODUCED IN CULTURED MUSCLE [J].
ASKANAS, V ;
ENGEL, WK ;
DIMAURO, S ;
BROOKS, BR ;
MEHLER, M .
NEW ENGLAND JOURNAL OF MEDICINE, 1976, 294 (11) :573-578
[6]   ULTRASTRUCTURE OF GUNN RAT SUBSTANTIA NIGRA .1. CYTOPLASMIC CHANGES [J].
BATTY, HK ;
MILLHOUSE, OE .
ACTA NEUROPATHOLOGICA, 1976, 35 (02) :93-107
[8]   CORRELATION OF NEONATAL SERUM TOTAL BILIRUBIN CONCENTRATIONS AND DEVELOPMENTAL STATUS AT AGE EIGHT MONTHS [J].
BOGGS, TR ;
HARDY, JB ;
FRAZIER, TM .
JOURNAL OF PEDIATRICS, 1967, 71 (04) :553-+
[9]  
BUTCHER RE, 1971, AM J MENT DEF, V75, P755
[10]   MECHANISM OF BILIRUBIN TOXICITY STUDIED WITH PURIFIED RESPIRATORY ENZYME AND TISSUE CULTURE SYSTEMS [J].
COWGER, ML ;
IGO, RP ;
LABBE, RF .
BIOCHEMISTRY, 1965, 4 (12) :2763-+