QUANTITATIVE COMPARISON OF BARBITURATES IN ESSENTIAL HAND AND HEAD TREMOR

被引：23

作者：

SASSO, E ^{[1
]}

PERUCCA, E ^{[1
]}

FAVA, R ^{[1
]}

CALZETTI, S ^{[1
]}

机构：

[1] UNIV PARMA,IST NEUROL,ST QUARTIERE 4,I-43100 PARMA,ITALY

来源：

MOVEMENT DISORDERS | 1991年 / 6卷 / 01期

关键词：

ESSENTIAL TREMOR; PRIMIDONE; PHENOBARBITAL; ACCELEROMETRY;

D O I：

10.1002/mds.870060112

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The tremorolytic effects of primidone and phenobarbital in essential tremor of hands and head were compared in a double-blind, placebo-controlled trial. Quantitative measurements of tremor were obtained in 15 patients by means of an accelerometric method. Only primidone proved to be superior to placebo in reducing hand tremor, suggesting that its tremorolytic effectiveness is largely dependent on the parent drug rather than its metabolite phenobarbital. Head tremor tended to improve only in three out of six patients with both primidone and phenobarbital, but, likely due to the small number of affected patients, the effect failed to reach statistical significance.

引用

页码：65 / 68

页数：4

共 15 条

[1]

O'Brien MD, Upton AR, Toseland PA., Benign familial tremor treated with primidone, Br Med J, 282, pp. 178-180, (1981)

[2]

Findley LJ, Calzetti S., Double‐blind controlled study of primidone in essential tremor: preliminary results, Br Med J, 285, (1982)

[3]

Findley LJ, Cleeves L, Calzetti S., Primidone in essential tremor of hands and head: a double‐blind controlled study, J Neurol Neurosurg Psychiatry, 48, pp. 911-915, (1985)

[4]

Gorman WP, Cooper R, Pocock P, Campbell MJ., A comparison of primidone propranolol and placebo in essential tremor using quantitative analysis, J Neurol Neurosurg Psychiatry, 49, pp. 64-68, (1986)

[5]

Dietrichson P, Espen E., Primidone and propranolol in essential tremor: a study based on quantitative tremor recording and plasma anticonvulsant levels, Acta Neurol Scand, 75, pp. 332-340, (1987)

[6]

Baruzzi A, Procaccianti G, Martinelli P, Et al., Phenobarbital and propranolol in essential tremor: a double‐blind controlled clinical trial, Neurology, 33, pp. 296-300, (1983)

[7]

Sasso E, Perucca E, Calzetti S., Double‐blind comparison of primidone and phenobarbital in essential tremor, Neurology, 38, pp. 808-810, (1988)

[8]

Koller WC, Royse VL., Efficacy of primidone in essential tremor, Neurology, 36, pp. 121-124, (1986)

[9]

Sasso E, Perucca E, Fava R, Calzetti S., Primidone in the long‐term treatment of essential tremor: a prospective study with computerized quantitative analysis, Clin Neuropharmacol, 13, pp. 67-76, (1990)

[10]

Calzetti S, Findley LJ, Pisani F, Richens A., Phenylethylmalonamide in essential tremor: a double‐blind, controlled study, J Neurol Neurosurg Psychiatry, 44, pp. 932-934, (1982)

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