CHANGES IN THE D1 RECEPTOR-ADENYLATE CYCLASE COMPLEX AFTER PRIMING

被引：29

作者：

MORELLI, M ^{[1
]}

DEMONTIS, G ^{[1
]}

DICHIARA, G ^{[1
]}

机构：

[1] UNIV CAGLIARI,INST PHARMACOL & BIOCHEM PATHOL,I-09100 CAGLIARI,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 180卷 / 2-3期

关键词：

6-Hydroxydopamine (6-OHDA); Adenylate-cyclase; Dopamine; Dopamine D[!sub]1[!/sub] receptors;

D O I：

10.1016/0014-2999(90)90323-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The D1 agonist, SKF 38393, failed to induce contralateral turning in drug-naive rats lesioned unilaterally with 6-hydroxydopamine from 17 days. Priming with a dopamine agonist, such as the D2 agonist, LY 171555, three days before, made SKF 38393 fully effective in inducing contralateral turning. Analysis of D1 receptor binding in striata of drug-naive and primed rats showed no change in the Bmax and Kd. In contrast, dopamine-stimulated adenylate cyclase showed a decrease in its Km for dopamine in the lesioned side of primed rats as compared with drug-naive rats. Thus, priming appears to elicit changes at the level of the transduction mechanism of D1 receptors rather than in the D1 recognition site itself. © 1990.

引用

页码：365 / 367

页数：3

共 9 条

[1] CHARACTERIZATION OF THE BINDING OF H-3-SCH 23390, A SELECTIVE D-1 RECEPTOR ANTAGONIST LIGAND, IN RAT STRIATUM [J].