HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF IOTHALAMIC ACID IN HUMAN PLASMA AND URINE

被引:15
作者
GASPARI, F
MAINARDI, L
RUGGENENTI, P
REMUZZI, G
机构
[1] Mario Negri Institute for Pharmacological Research, Laboratory of Clinical Pharmacokinetics, 24100 Bergamo
来源
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 570卷 / 02期
关键词
D O I
10.1016/0378-4347(91)80550-V
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A simple, rapid and sensitive method for the determination of iothalamic acid (IA) in both plasma and urine is reported. After extraction with ethyl acetate, IA was determined by strong anion-exchange high-performance liquid chromatography with ultraviolet detection at 254 nm. The lower limit of detection was 0.5-mu-g/ml. The average recovery was 73 and 57% from plasma and urine, respectively. Linearity was found over the investigated concentration range (up to 500-mu-g/ml for plasma and up to 10.0 mg/ml for urine). The reproducibility of the technique was good (coefficient of variation less than 6%) as was the precision and accuracy (coefficient of variation less than 2.5%). No interference from endogenous substances or any of the common drugs tested was found.
引用
收藏
页码:435 / 440
页数:6
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