NEWLY GENERATED IGE ANTIBODIES TO DERMATOPHAGOIDES-PTERONYSSINUS IN CHILDREN ARE DIRECTED AGAINST COMPONENTS DISTINCT FROM DER-P-I AND DER-P-II

被引：14

作者：

CALKHOVEN, PG

AALBERS, M

SCHILTE, PPM

YNTEMA, BJL

GRIFFIOEN, RW

VANNIEROP, JC

ORANJE, AP

AALBERSE, RC

机构：

[1] NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB,POB 9406,1006 AK AMSTERDAM,NETHERLANDS

[2] UNIV AMSTERDAM,EXPTL & CLIN IMMUNOL,AMSTERDAM,NETHERLANDS

[3] MED CTR ALKMAAR,ALKMAAR,NETHERLANDS

[4] EMMA CHILDRENS HOSP,AMSTERDAM,NETHERLANDS

[5] UNIV HOSP ROTTERDAM,SOPHIA CHILDRENS HOSP,ROTTERDAM,NETHERLANDS

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 1991年 / 88卷 / 02期

关键词：

HOUSE DUST MITE; DERMATOPHAGOIDES PTERONYSSINUS; IGE-MEDIATED ALLERGY; DER-P-I; DER-P-II;

D O I：

10.1016/0091-6749(91)90337-N

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The specificity of newly generated IgE antibodies (Abs) to the house dust mite, Dermatophagoides pteronyssinus, in longitudinal serum samples from 18 young children with an increased risk for IgE-mediated allergy was studied. The first IgE Ab response to house dust mite was detected early in life (mean age, 32 months; range, 11 to 60 months). For 83% of the children, more than half of the newly generated IgE Ab response to house dust mite was directed against components distinct from the major allergens, Der p I (P1) and Der p II (DpX). These results suggest that the early IgE Ab response to house dust mite is induced by components distinct from the major allergens, Der P I and Der p II.

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页码：265 / 271

页数：7

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