COMPARISON OF DEXMEDETOMIDINE AND MIDAZOLAM SEDATION AND ANTAGONISM OF DEXMEDETOMIDINE WITH ATIPAMEZOLE

被引：58

作者：

AHO, M

ERKOLA, O

KALLIO, A

SCHEININ, H

KORTTILA, K

机构：

[1] Departments of Anesthesia, Women's Hospital, Helsinki University Central Hospital, Helsinki

[2] Orion Corporation, Farmos Research Center, Turku

来源：

JOURNAL OF CLINICAL ANESTHESIA | 1993年 / 5卷 / 03期

关键词：

ALPHA-ADRENERGIC AGONISTS; ALPHA-ADRENERGIC ANTAGONISTS; ATIPAMEZOLE; ANESTHESIA; HEMODYNAMICS; DEXMEDETOMIDINE; RECEPTORS; ALPHA-2-ADRENERGIC; SYMPATHETIC NERVOUS SYSTEM;

D O I：

10.1016/0952-8180(93)90014-6

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Study Objective: To evaluate the effects of dexmedetomidine, an alpha-2 agonist, as an intravenous sedative drug and the effects of atipamezole, an alpha-2 antagonist, on recovery. Design: Randomized, double-blind study with three parallel groups. An open dose-finding study preceded it to optimize the atipamezole dose. Setting: Outpatient operating room at the gynecologic and obstetric university hospital in Helsinki, Finland. Patients: Seventy-two healthy women scheduled for legal termination of pregnancy. Interventions: Patients were assigned to one of three groups of 24 patients each to receive either dexmedetomidine 2 mug/kg and atipamezole 50 mug/kg; dexmedetomidine 2 mug/kg and saline; or midazolam 0.15 mg/kg and saline. In addition to paracervical block, each patient received two different study drugs: study drug 1 was a sedative agent (either dexmedetomidine or midazolam), administered before the procedure. If the sedation was not deep enough and the patient reacted to the procedure, a low dose of propofol was administered. Study drug 2 was a reversing agent or a placebo, administered following the procedure. Measurements and Main Results: The mean time to regain consciousness was shorter in the dexmedetomidine-atipamezole and the dexmedetomidine-saline groups compared with the midazolam group. Postoperative sedation, tested both by subjective and objective assessments, decreased more quickly in the dexmedetomidine-atipamezole group compared with the dexmedetomidine-saline and the midazolam groups. Conclusion: Atipamezole is an effective antagonist for reversing psychomotor impairment following dexmedetomidine sedation.

引用

页码：194 / 203

页数：10

共 29 条

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