TRANSCRIPTIONAL ANTITERMINATION

被引：224

作者：

GREENBLATT, J ^{[1
]}

NODWELL, JR ^{[1
]}

MASON, SW ^{[1
]}

机构：

[1] UNIV TORONTO,DEPT MOLEC & MED GENET,TORONTO M5G 1L6,ONTARIO,CANADA

来源：

NATURE | 1993年 / 364卷 / 6436期

关键词：

D O I：

10.1038/364401a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Antiterminator proteins control gene expression by recognizing control signals near the promoter and preventing transcriptional termination which would otherwise occur at sites that may be a long way downstream. The N protein of bacteriophage lambda recognizes a sequence in the nascent RNA, and modifies RNA polymerase by catalysing the formation of a stable ribonucleo-protein complex on its surface, whereas the lambda Q protein recognizes a sequence in the DNA. These mechanisms of antitermination in lambda provide models for analysing antitermination in viruses such as HIV-1 and in eukaryotic genes.

引用

页码：401 / 406

页数：6

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