TECHNIQUES FOR THE MEASUREMENT OF THE LOCAL MYOCARDIAL EXTRACTION EFFICIENCY FOR INERT DIFFUSIBLE CONTRAST AGENTS SUCH AS GADOPENTATE DIMEGLUMINE

被引：43

作者：

TONG, CY

PRATO, FS

WISENBERG, G

LEE, TY

CARROLL, E

SANDLER, D

WILLS, J

机构：

[1] UNIV WESTERN ONTARIO, ST JOSEPHS HLTH CTR, LAWSON RES INST, DEPT RADIOL, LONDON N6A 3K7, ONTARIO, CANADA

[2] UNIV WESTERN ONTARIO, ST JOSEPHS HLTH CTR, LAWSON RES INST, DEPT PHYS, LONDON N6A 3K7, ONTARIO, CANADA

[3] UNIV WESTERN ONTARIO, ST JOSEPHS HLTH CTR, LAWSON RES INST, DEPT MED, LONDON N6A 3K7, ONTARIO, CANADA

[4] UNIV WESTERN ONTARIO, ST JOSEPHS HLTH CTR, LAWSON RES INST, DEPT NUCL MED, LONDON N6A 3K7, ONTARIO, CANADA

[5] UNIV WESTERN ONTARIO, ST JOSEPHS HLTH CTR, LAWSON RES INST, DEPT SURG, LONDON N6A 3K7, ONTARIO, CANADA

来源：

MAGNETIC RESONANCE IN MEDICINE | 1993年 / 30卷 / 03期

关键词：

EXTRACTION EFFICIENCY; CONTRAST AGENTS; FLOW QUANTIFICATION; MYOCARDIAL INFARCTION;

D O I：

10.1002/mrm.1910300309

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We have previously shown that the concentration of Gd-DTPA as a function of time ([Gd-DTPA]t(t)) in the myocardium following an intravenous bolus injection of Gd-DTPA can be modeled using the Modified Kety Equation. Fitting this model to measurements of [Gd-DTPA]t(t) in a region of myocardium would allow the determination of myocardial distribution volume (lambda) and the product of flow (F) and extraction efficiency (E), i.e., FE. Thus, to measure F, E must be known. We describe here techniques developed to measure local values of E in normal and diseased myocardium. These techniques are valid for any inert diffusible MR contrast agent.

引用

页码：332 / 336

页数：5

共 17 条

[1] QUANTIFICATION OF REGIONAL MYOCARDIAL BLOOD-FLOW INVIVO WITH (H2O)-O-15 [J].