THE CHIMERIC RECEPTOR BETWEEN INTERLEUKIN-2 RECEPTOR-BETA CHAIN AND INTERLEUKIN-4 RECEPTOR TRANSDUCES INTERLEUKIN-2 SIGNAL

被引：17

作者：

IZUHARA, K ^{[1
]}

MIYAJIMA, A ^{[1
]}

HARADA, N ^{[1
]}

机构：

[1] DNAX RES INST MOLEC & CELLULAR BIOL INC,DEPT MOLEC BIOL,PALO ALTO,CA 94304

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 190卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.1147

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transfectants expressing the chimeric receptor which has human interleukin-4 receptor (hIL-4R) in the extracellular domain and human interleukin-2 receptor β chain (hIL-2Rβ) in the cytoplasmic domain showed continuous growth in response to human interleukin-4 (hIL-4), whereas transfectants expressing hIL-4R responded only transiently to hIL-4. The pattern of tyrosine phosphorylation induced by hIL-4 in transfectants expressing the chimeric receptor was very similar to that in transfectants expressing hIL-2Rβ, but different from that in transfectants expressing hIL-4R, indicating that the chimeric receptor transduces the interleukin-2 like growth signal by hIL-4. © 1993 Academic Press.

引用

页码：992 / 1000

页数：9

共 28 条

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