ENHANCED BFGF GENE-EXPRESSION IN RESPONSE TO TRANSFORMING GROWTH-FACTOR-BETA STIMULATION OF AKR-2B CELLS

被引：20

作者：

PERTOVAARA, L

SAKSELA, O

ALITALO, K

机构：

[1] UNIV HELSINKI,DEPT PATHOL,MOLEC CANC BIOL LAB,HAARTMANINKATU 3,SF-00290 HELSINKI 29,FINLAND

[2] UNIV HELSINKI,DEPT VIROL,SF-00290 HELSINKI 29,FINLAND

来源：

GROWTH FACTORS | 1993年 / 9卷 / 01期

关键词：

TGF-BETA; BFGF;

D O I：

10.3109/08977199308991584

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Treatment of quiescent cultures of mouse embryo-derived AKR-2B cells with transforming growth factor beta resulted in an induction of basic fibroblast growth factor (bFGF) mRNA and bFGF protein in the stimulated cells. In contrast to bFGF, acidic fibroblast growth factor (aFGF) was not induced by TGFbeta. The mitogenic effect of transforming growth factor beta on AKR-2B cells may be mediated by the induction of bFCF in these cells.

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页码：81 / 86

页数：6

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