THE PROTEIN-CONDUCTING CHANNEL IN THE MEMBRANE OF THE ENDOPLASMIC-RETICULUM IS OPEN LATERALLY TOWARD THE LIPID BILAYER

被引：238

作者：

MARTOGLIO, B ^{[1
]}

HOFMANN, MW ^{[1
]}

BRUNNER, J ^{[1
]}

DOBBERSTEIN, B ^{[1
]}

机构：

[1] ETH ZURICH, BIOCHEM LAB, CH-8092 ZURICH, SWITZERLAND

来源：

CELL | 1995年 / 81卷 / 02期

关键词：

D O I：

10.1016/0092-8674(95)90330-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipids and proteins were found to contact a nascent type II membrane protein, as well as a nascent secretory protein, during their insertion into the membrane of the endoplasmic reticulum. This suggests that the protein-conducting channel is open laterally toward the lipid bilayer during an early stage of protein insertion. Contact to lipids was confined to the hydrophobic core region of the respective signal or signal anchor sequence. Thus, the nascent polypeptide is positioned in the translocation complex such that the signal or signal anchor sequence faces the lipid bilayer, whereas the hydrophilic, translocating portion is in proteinaceous environment.

引用

页码：207 / 214

页数：8

共 42 条

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