Apoptosis in myelodysplasia: A paradox or paradigm

被引：37

作者：

Yoshida, Y

Anzai, N

Kawabata, H

机构：

[1] The First Division, Department of Medicine, Faculty of Medicine, Kyoto

来源：

LEUKEMIA RESEARCH | 1995年 / 19卷 / 12期

关键词：

mechanism(s) of apoptotic cell death; myelodysplastic syndromes; ineffective hematopoiesis; leukemic transformation;

D O I：

10.1016/0145-2126(95)00100-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A growing body of evidence indicates that certain diseases are associated with increased apoptosis or inhibition of apoptosis. Among them, the myelodysplastic syndromes (MDS) are unique in that apoptosis is related, in apparently opposite directions, to the various facets of MDS. Ineffective hematopoiesis may be related to excessive intramedullary cell death via apoptosis and leukemic transformation conceivably results from escape from the apoptotic control. Future studies should be directed to define cellular susceptibility to and circumvention from apoptotic control mechanism(s).

引用

页码：887 / 891

页数：5

共 31 条

[1]

ANZAI N, 1995, BLOOD, V86, P917

[2]

ANZAI N, 1994, LEUKEMIA, V8, P446

[3] PROPOSALS FOR THE CLASSIFICATION OF THE MYELODYSPLASTIC SYNDROMES [J].