Genome scanning for complex disease genes using the transmission/disequilibrium test and haplotype-based haplotype relative risk

被引:5
作者
Matise, TC
机构
[1] Department of Psychiatry, Columbia University, New York, New York
关键词
allelic association; transmission disequilibrium; haplotype relative risk;
D O I
10.1002/gepi.1370120620
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Two tests for allelic association were applied to a simulated complex disease for the Genetic Analysis Workshop 9. The transmission/disequilibrium test [Spielman et al., 1993] and the haplotype-based haplotype relative risk approach [Terwilliger and Ott, 1992] were used to detect disease-associated alleles in a set of 360 computer-simulated markers located on six chromosomes and genotyped in 200 nuclear families. This analysis emulates a genome-based search for linked markers. Computer simulations were also performed to clarify statistical properties of the TDT. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码:641 / 645
页数:5
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