ANTIGENIC VARIATION OF WILD AND VACCINE RABIES STRAINS OF EGYPT

被引：3

作者：

BOTROS, BAM ^{[1
]}

SALIB, AW ^{[1
]}

MELLICK, PW ^{[1
]}

LINN, JM ^{[1
]}

SOLIMAN, AK ^{[1
]}

SCOTT, RM ^{[1
]}

机构：

[1] USN, MED RES UNIT 3, CAIRO, EGYPT

来源：

JOURNAL OF MEDICAL VIROLOGY | 1988年 / 24卷 / 02期

关键词：

D O I：

10.1002/jmv.1890240204

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nineteen street rabies virus strains, isolated in Egypt from humans (two), dogs (nine), cats (two), farm animals (two), gerbils (three), and a jackal were antigenically analyzed. The Pasteur strain used for the preparation of human rabies vaccine, the Flury high and low egg passage strains (HEP, LEP) used for animal vaccines, and the challenge virus standard (CVS) strain were also assayed. All were examined by the indirect fluorescent antibody test, using a panel of 20 monoclonal antibodies against the nucleocapsid of rabies and rabies-related viruses. The rabies isolates demonstrated patterns of reactivity with the antinucleocapsid panel different from those of the Pasteur, HEP, and CVS strains. Representative human, dog, and rodent isolates were analyzed by neutralization tests in mice, with a second panel of 19 monoclonal antibodies against rabies and Mokola envelope glycoproteins. With this panel, the isolates demonstrated patterns of reactivity different from the vaccine strains. These data indicate antigenic variation betwen wild virus and vaccine strains.

引用

页码：153 / 159

页数：7

共 15 条

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