MECHANISM OF CONVERSION OF DETHIOBIOTIN TO BIOTIN IN ESCHERICHIA-COLI .3. ISOLATION OF AN INTERMEDIATE IN THE BIOSYNTHESIS OF BIOTIN FROM DETHIOBIOTIN (1,2)

被引：16

作者：

SALIB, AG ^{[1
]}

FRAPPIER, F ^{[1
]}

GUILLERM, G ^{[1
]}

MARQUET, A ^{[1
]}

机构：

[1] CNRS,CTR ETUD & RECH CHIM ORGAN APPL,F-94320 THIAIS,FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 88卷 / 01期

关键词：

D O I：

10.1016/0006-291X(79)91731-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An intermediate in the biosynthetic pathway between dethiobiotin and biotin has been isolated for the first time, from the incubation medium of resting cells of E. Coli C124 (bio A-, His-) with ∥3H∥ or/and ∥14C∥ dethiotiotin. This compound contains sulfur. It promotes the growth of E. Coli 124 as well as other strains which are strictly biotin requiring, i.e. blocked between dethiobiotin and biotin. The conversion of the labeled intermediate into biotin by growing cells of E. Coli C124 has been established. © 1979.

引用

页码：312 / 319

页数：8

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