RAPID CI-MS DETERMINATION OF VALPROIC ACID - ADAPTATION OF A GAS-CHROMATOGRAPHIC ASSAY

被引：5

作者：

BALKON, J ^{[1
]}

机构：

[1] LONG ISL JEWISH HILLSIDE MED CTR, DEPT LABS TOXICOL LAB, POB 38, GLEN OAKS, NY 11004 USA

来源：

JOURNAL OF ANALYTICAL TOXICOLOGY | 1979年 / 3卷 / 02期

关键词：

D O I：

10.1093/jat/3.2.78

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Adaptation of a gas chromatographic method for valproic acid to a determination using chemical ionization mass spectrometry (CI-MS) is reported. Using the mass spectrometer as a gas chromatographic effluent monitor, valproic acid and paramethadione (an internal standard) concentrations are followed at m/e [mass charge ratio] 145 and 158, respectively. Quantitation is achieved by measurement of the specific chromatographic area attributable to each of these substances. The method offers the advantages of high specificity and reproducibility, with short (less than 1 min) chromatographic elution times.

引用

页码：78 / 79

页数：2