INADVERTENT TRANSMISSION OF A DONORS ACUTE MYELOID-LEUKEMIA IN BONE-MARROW TRANSPLANTATION FOR CHRONIC MYELOCYTIC-LEUKEMIA

被引：77

作者：

NIEDERWIESER, DW

APPELBAUM, FR

GASTL, G

GERSDORF, E

MEISTER, B

GEISSLER, D

TRATKIEWICZ, JA

THALER, J

HUBER, C

机构：

[1] UNIV INNSBRUCK, DEPT INTERNAL MED, A-6020 INNSBRUCK, AUSTRIA

[2] UNIV INNSBRUCK, DEPT MED BIOL & GENET, A-6020 INNSBRUCK, AUSTRIA

[3] FRED HUTCHINSON CANC RES CTR, SEATTLE, WA 98104 USA

[4] UNIV WASHINGTON, SCH MED, DIV ONCOL, SEATTLE, WA 98195 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 1990年 / 322卷 / 25期

关键词：

D O I：

10.1056/NEJM199006213222507

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A PATIENT with Philadelphia chromosome-positive chronic myelocytic leukemia in a phase of accelerated growth received a bone marrow transplant from her HLA-identical brother, whose cells were not reactive in the mixed leukocyte culture. Although routine examination of the donor's peripheral blood before transplantation revealed no abnormalities, the bone marrow graft showed acute myeloid leukemia, with 38 percent leukemic blasts. The infusion of this leukemic bone marrow resulted in normal engraftment, with complete chimerism two months after transplantation. The specific cytogenetic abnormalities of both the donor and the host leukemias disappeared one month after transplantation and remained undetectable for four more… © 1990, Massachusetts Medical Society. All rights reserved.

引用

页码：1794 / 1796

页数：3

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