MULLERIAN DUCT REGRESSION IN THE EMBRYO CORRELATED WITH CYTOTOXIC ACTIVITY AGAINST HUMAN OVARIAN-CANCER

被引：67

作者：

DONAHOE, PK

SWANN, DA

HAYASHI, A

SULLIVAN, MD

机构：

[1] HARVARD UNIV, MASSACHUSETTS GEN HOSP, SCH MED, DEPT SURG, BOSTON, MA 02114 USA

[2] HARVARD UNIV, MASSACHUSETTS GEN HOSP, SCH MED, DEPT BIOL CHEM, BOSTON, MA 02114 USA

来源：

SCIENCE | 1979年 / 205卷 / 4409期

关键词：

D O I：

10.1126/science.472712

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A significant cytotoxicity index was obtained when human ovarian cancer cells in a microcytotoxicity assay were exposed during the S (DNA-synthesizing) phase of the cell cycle to purified fractions of testis exhibiting high Müllerian inhibiting substance bioactivity. The same effect was not observed when these fractions were tested against human glioblastoma or fibroblast lines. Most human ovarian cancers are said to resemble Müllerian tissues histologically. Müllerian inhibiting substance may thus deserve further study as a potential chemotherapeutic agent. Copyright © 1979 AAAS.

引用

页码：913 / 915

页数：3

共 29 条

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[8] 2-2
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