SIMULATION OF COMPARTMENTAL-MODELS FOR KINETIC DATA FROM A POSITRON EMISSION TOMOGRAPH

被引:21
作者
COXSON, PG [1 ]
SALMERON, EM [1 ]
HUESMAN, RH [1 ]
MAZOYER, BM [1 ]
机构
[1] SERV HOSP FREDERIC JOLIOT,ORSAY,FRANCE
关键词
COMPARTMENTAL MODELS; TRACER KINETICS; POSITRON EMISSION TOMOGRAPHY; MATRIX EXPONENTIAL; CONVOLUTION;
D O I
10.1016/0169-2607(92)90116-O
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
Linear compartmental models are used to describe the disposition of radio-labelled compounds in regions of interest in the mammalian body, based on a time sequence of measurements from a positron emission tomograph (PET). In this paper we show how closed form solutions for the model equations have been incorporated into a computer program for simulation and parameter estimation. A typical PET data example is included to illustrate the implementation and compare the closed form method with a numerical ode solution method.
引用
收藏
页码:205 / 214
页数:10
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