TRICYCLIC ANALOGS OF MELATONIN

被引：34

作者：

KOBAYASHI, T

SPANDE, TF

AOYAGI, H

WITKOP, B

机构：

[1] Laboratary of Chemistry, National Institute of Arthritis and Metabolic Diseases, National institutes of Health, Bethesda

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 04期

关键词：

D O I：

10.1021/jm00304a017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The angular tricyclic analog of melatonin, 8-methoxy-6-oxo-3,4,6,7-tetrahydro-1H,5H-azocin[4,5,6-cd]indole (IV) as well as the linear “dehydromelatonin” viz., 5-methoxy-1-acetyl-2,3-dihydropyrrolo[2,3-b]indole (VI) had retained only tiny fractions of the activity of melatonin. The lactam IV and the corresponding amine V showed no major CNS effects in mice and cats. © 1969, American Chemical Society. All rights reserved.

引用

页码：636 / +

页数：1

共 6 条

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