BACLOFEN DOES NOT PROTECT AGAINST CEREBRAL-ISCHEMIA IN RATS

被引：30

作者：

ROSENBAUM, DM ^{[1
]}

GROTTA, JC ^{[1
]}

PETTIGREW, LC ^{[1
]}

OSTROW, P ^{[1
]}

STRONG, R ^{[1
]}

RHOADES, H ^{[1
]}

PICONE, CM ^{[1
]}

GROTTA, AT ^{[1
]}

机构：

[1] UNIV TEXAS,HLTH SCI CTR,SCH MED,DEPT NEUROL,6431 FANNIN,MSB 7044,HOUSTON,TX 77030

来源：

STROKE | 1990年 / 21卷 / 01期

关键词：

Baclofen; Cerebral ischemia; Rats;

D O I：

10.1161/01.STR.21.1.138

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Presynaptic release of glutamate into the extracellular compartment and activation of receptor-operated calcium channels may contribute to ischemic neuronal damage. We evaluated the effect of baclofen, a selective inhibitor of presynaptic glutamate release, on mortality, working memory, and light microscopic hippocampal and cortical damage in the four-vessel occlusion model of cerebral ischemia using 64 male Wistar rats. Baclofen (10 mg/kg i.p.) given 1 hour before and 30-60 minutes after 20 minutes of global ischemia did not lessen mortality, prevent ischemic cellular damage, or significantly improve working memory compared with no treatment We conclude that preischemic and postischemic administration of baclofen does not protect neurons from ischemic injury. © 1990 American Heart Association, Inc.

引用

页码：138 / 140

页数：3

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