PLASMA CONCENTRATIONS OF PROPRANOLOL AND 4-HYDROXYPROPRANOLOL IN MAN MEASURED BY HIGH-PRESSURE LIQUID-CHROMATOGRAPHY

被引：38

作者：

TABURET, AM

TAYLOR, AA

MITCHELL, JR

ROLLINS, DE

POOL, JL

机构：

[1] NHLBI,HYPERTENS ENDOCRINE BRANCH,BETHESDA,MD 20014

[2] NHLBI,CLIN PHARMACOL & METAB SECT,BETHESDA,MD 20014

来源：

LIFE SCIENCES | 1979年 / 24卷 / 03期

关键词：

D O I：

10.1016/0024-3205(79)90221-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A quantitative method for the simultaneous determination of propranolol and its major active metabolite, 4-hydroxypropranolol, in human plasma is described using high pressure liquid chromatography. As little as 1.5 ng/ml of propranolol and 5 ng/ml of 4-hydroxypropranolol can be measured with good precision by a fluorometric detector. Triamterene and quinidine are the only commonly used cardiovascular drugs that interfere with the assay. The pharmacokinetics of propranolol and 4-hydroxypropranolol were studied in three patients following oral administration of various dosages of propranolol. High pressure liquid chromatography allows more rapid analysis of plasma propranolol and 4-hydroxypropranolol concentrations than gas chromatographic-mass spectrometric methods, without sacrificing specificity or sensitivity. © 1979.

引用

页码：209 / 217

页数：9

共 16 条

[1]

AMBLER PK, 1974, ACTA CLIN CHIM, V54, P373

[2]

EVANS GH, 1973, J PHARMACOL EXP THER, V186, P114

[3]

EVANS GH, 1973, CLIN PHARMACOL THER, V14, P494

[4] PHARMACOLOGY OF 4-HYDROXYPROPRANOLOL, A METABOLITE OF PROPRANOLOL [J].