SYNTHESIS OF SUBSTITUTED 2-AMINOPYRROLE ANALOGS OF LIDOCAINE .1.

被引：9

作者：

JOHNSON, RW ^{[1
]}

KEENAN, TH ^{[1
]}

KOSH, JW ^{[1
]}

SOWELL, JW ^{[1
]}

机构：

[1] UNIV S CAROLINA,COLL PHARM,COLUMBIA,SC 29208

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 03期

关键词：

2‐Aminopyrrole analogs of lidocaine; various—synthesized; evaluated for local anesthetic activity in guinea pigs and antiarrhythmic activity in mice; Lidocaine analogs—2‐aminopyrroles synthesized; Structure‐activity relationships—various 2‐aminopyrrole analogs of lidocaine evaluated for local anesthetic activity in guinea pigs and antiarrhythmic activity in mice;

D O I：

10.1002/jps.2600680316

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis, local anesthetic, and antiarrhythmic properties of nine 2‐diethylaminoacetamido‐3‐cyano‐4‐methyl‐5‐substituted pyrroles are described. All compounds showed local anesthetic activity by the guinea pig wheal test and antiarrhythmic activity for chloroform‐induced ventricular arrhythmias in mice. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：317 / 320

页数：4

共 11 条

[1]

ACHESON RM, 1967, INTRO CHEM HETEROCYC, P78

[2]

BOYES RN, 1971, CLIN PHARMACOL THER, V12, P105

[3]

BULBRING E, 1945, J PHARMACOL EXP THER, V85, P78

[4]

Gewald K., 1961, Z CHEM, V1, P349

[5]

HOLLUNGER GUNNAR, 1960, ACTA PHARMACOL ET TOXICOL, V17, P365

[6]

HOLLUNGER GUNNAR, 1960, ACTA PHARMACOL ET TOXICOL, V17, P356

[7] SYNTHESIS OF SUBSTITUTED 2-AMINO-3-CYANO-4-METHYLPYRROLES [J].

JOHNSON, RW ;

MATTSON, RJ ;

SOWELL, JW .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1977, 14 (03) :383-385

[8]

LAWSON JW, 1968, J PHARMACOL EXP THER, V160, P22

[9]

LOFGREN NM, 1948, CHEM ABSTR 6378G, V42

[10]

SHVEDOV VI, 1975, KHIM GETEROTSIKL SOE, V9, P1219

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