POTENTIATION OF HALOTHANE ANESTHESIA BY CLONIDINE

被引：84

作者：

KAUKINEN, S ^{[1
]}

PYYKKO, K ^{[1
]}

机构：

[1] UNIV TAMPERE,DEPT BIOMED SCI,SF-33101 TAMPERE 10,FINLAND

来源：

ACTA ANAESTHESIOLOGICA SCANDINAVICA | 1979年 / 23卷 / 01期

关键词：

D O I：

10.1111/j.1399-6576.1979.tb01429.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The antihypertensive agent, clonidine, has a marked sedative effect. We studied whether clonidine also deepens halothane anaesthesia. Eight rabbits were anaesthetized with and without clonidine premedication in a cross‐over study. Clonidine premedication (50 μg/kg subcutaneously) was administered three times daily for 3 days. Tolerance to pain during halothane anaesthesia was tested by compressing the ear with a vessel clamp. Halothane concentrations were determined by gas chromatography. The rabbits premedicated with clonidine tolerated painful stimuli without reactions at lower halothane concentrations in arterial blood and inspired air than unpremedicated rabbits. MAC calculated from blood concentrations was 1.29% for unpremedicated and 1.09% for clonidine‐premedicated rabbits. The results suggest that clonidine diminishes the anaesthetic requirement in halothane anaesthesia. © 1979 Acta Anaesthesiologica Scandinavica Fonden

引用

页码：107 / 111

页数：5

共 24 条

[1] DETERMINATION OF HALOTHANE IN GAS, BLOOD, AND TISSUES BY CHEMICAL EXTRACTION AND GAS CHROMATOGRAPHY [J].

ALLOTT, PR ;

STEWARD, A ;

MAPLESON, WW .

BRITISH JOURNAL OF ANAESTHESIA, 1971, 43 (10) :913-&

[2] DIFFERENT ALPHA-ADRENORECEPTORS IN CENTRAL NERVOUS-SYSTEM MEDIATING BIOCHEMICAL AND FUNCTIONAL EFFECTS OF CLONIDINE AND RECEPTOR BLOCKING-AGENTS [J].

ANDEN, NE ;

GRABOWSKA, M ;

STROMBOM, U .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1976, 292 (01) :43-52

[3] EVIDENCE FOR A CENTRAL NORADRENALINE RECEPTOR STIMULATION BY CLONIDINE [J].

ANDEN, NE ;

CORRODI, H ;

FUXE, K ;

HOKFELT, B ;

HOKFELT, T ;

RYDIN, C ;

SVENSSON, T .

LIFE SCIENCE PART 1 PHYSIOLOGY & PHARMACOLOGY, 1970, 9 (09) :513-&

[4] EFFECT OF CLONIDINE ON SLEEP PATTERNS IN MAN [J].

AUTRET, A ;

MINZ, M ;

BEILLEVAIRE, T ;

CATHALA, HP ;

SCHMITT, H .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1977, 12 (05) :319-322

[5]

BRODSKY JB, 1976, ANESTHESIOLOGY, V44, P519

[6] DETERMINATION OF MINIMUM ALVEOLAR CONCENTRATION (MAC) OF HALOTHANE IN WHITE NEW-ZEALAND RABBIT [J].

DAVIS, NL ;

NUNNALLY, RL ;

MALININ, TI .

BRITISH JOURNAL OF ANAESTHESIA, 1975, 47 (03) :341-345

[7]

EGER EI, 1974, ANESTHETIC UPTAKE AC, P77

[8]

FLORIO V, 1975, NEUROPHARMACOLOGY, V14, P707, DOI 10.1016/0028-3908(75)90095-7

[9] BLOOD-PRESSURE AND HEART-RATE AND WITHDRAWAL OF ANTIHYPERTENSIVE DRUGS [J].

GOLDBERG, AD ;

RAFTERY, EB ;

WILKINSON, P .

BRITISH MEDICAL JOURNAL, 1977, 1 (6071) :1243-1246

[10]

HERBERT P, 1968, Journal of Medical Laboratory Technology, V25, P233

← 1 2 3 →