DETERMINATION OF ATRACURIUM AND LAUDANOSINE IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：18

作者：

VARIN, F ^{[1
]}

DUCHARME, J ^{[1
]}

BESNER, JG ^{[1
]}

THEORET, Y ^{[1
]}

机构：

[1] UNIV MONTREAL,DEPT PHARMACOL,MONTREAL H3C 3J7,QUEBEC,CANADA

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1990年 / 529卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0378-4347(00)83838-4

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatographic method coupled with fluorometric detection has been developed for the determination of atracurium and its major end-product laudanosine in human plasma. The method enables good separation of atracurium from its metabolites after direct precipitation of plasma proteins. The assay is sensitive, reproducible and linear for atracurium concentrations ranging from 31.25 to 8000 ng/ml. In a clinical setting, drugs commonly administered during anesthesia did not interfere with the assay. This method provides a simple and time-saving alternative to existing methods. © 1990.

引用

页码：319 / 327

页数：9

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