ASYMMETRIC REDUCTION OF 7,8-DIFLUORO-3-METHYL-2H-1,4-BENZOXAZINE - SYNTHESIS OF A KEY INTERMEDIATE OF (S)-(-)-OFLOXACIN (DR-3355)

被引：58

作者：

ATARASHI, S

TSURUMI, H

FUJIWARA, T

HAYAKAWA, I

机构：

[1] Research Institute, Daiichi Pharmaceutical Co, Ltd, Tokyo, 134, 1‐16‐13, Kitakasai, Edogawaku

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1991年 / 28卷 / 02期

关键词：

D O I：

10.1002/jhet.5570280222

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, highly enantioselective synthesis of (S)-(-)-7,8-difluoro-2,3-dihydro-3-methyl-4H-1,4-benzoxazine, a key intermediate of (S)-(-)-ofloxacin, using various chiral sodium triacyloxyborohydrides as reducing agents is reported.

引用

页码：329 / 331

页数：3

共 14 条

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