EXISTENCE OF HOST-RELATED DNA-SEQUENCES IN THE SCHISTOSOME GENOME

被引：20

作者：

IWAMURA, Y ^{[1
]}

IRIE, Y ^{[1
]}

KOMINAMI, R ^{[1
]}

NARA, T ^{[1
]}

YASURAOKA, K ^{[1
]}

机构：

[1] NIIGATA UNIV,SCH MED,NIIGATA 951,JAPAN

来源：

PARASITOLOGY | 1991年 / 102卷

关键词：

SCHISTOSOMA-JAPONICUM; SCHISTOSOMA-MANSONI; HOST-RELATED SEQUENCES; REPETITIVE SEQUENCES; MINI-SATELLITE (MO-2);

D O I：

10.1017/S0031182000064362

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

DNA sequences homologous to the mouse intracisternal A particle and endogenous type C retrovirus were detected in the DNAs of Schistosoma japonicum adults and S. mansoni eggs. Furthermore, other kinds of repetitive sequences in the host genome such as mouse type 1 Alu sequence (B1), mouse type 2 Alu sequence (B2) and mo-2 sequence, a mouse mini-satellite, were also detected in the DNAs from adults and eggs of S. japonicum and eggs of S. mansoni. Almost all of the sequences described above were absent in the DNAs of S. mansoni adults. The DNA fingerprints of schistosomes, using the mo-2 sequence, were indistinguishable from each other and resembled those of their murine hosts. Moreover, the mo-2 sequence was hypermethylated in the DNAs of schistosomes and its amount was variable in them. These facts indicate that host-related sequences are actually present in schistosomes and that the mo-2 repetitive sequence exists probably in extra-chromosome.

引用

页码：397 / 403

页数：7

共 20 条

[1] CLONED MOUSE MAMMARY-TUMOR VIRUS-DNA IS BIOLOGICALLY-ACTIVE IN TRANSFECTED MOUSE CELLS AND ITS EXPRESSION IS STIMULATED BY GLUCOCORTICOID HORMONES [J].