LOW-FREQUENCY NEAR-INFRARED FOURIER-TRANSFORM RAMAN STUDIES OF ELLIPTICINES AND DEOXYRIBOSE NUCLEIC-ACID

Nucleotides and nucleosides have been studied in the low-frequency region through a comparison of the performance between near-infrared Fourier transform Raman techniques and Ar+ -excitation Raman spectroscopy. This allowed us to evaluate the influence of the filter cut-off on the low-frequency bands of the Fourier transform Raman spectra. This assessment was then applied to a study of the low-frequency bands of two samples of deoxyribose nucleic acid and five ellipticines, whose interaction with deoxyribose nucleic acid could be of importance in their use as anti-cancer drugs. In order to assign the low-frequency bands of ellipticines and understand the dynamical ring deformations, a force constant calculation was performed.