THE CELLULAR AND MOLECULAR-BASIS FOR DIVERGENT ALLERGIC RESPONSES TO CHEMICALS

被引：19

作者：

DEARMAN, RJ

BASKETTER, DA

COLEMAN, JW

KIMBER, I

机构：

[1] UNILEVER RES LABS, ENVIRONM SAFETY LAB, SHARNBROOK MK44 1LQ, BEDS, ENGLAND

[2] UNIV LIVERPOOL, DEPT PHARMACOL & THERAPEUT, LIVERPOOL L69 3BX, ENGLAND

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1992年 / 84卷 / 01期

关键词：

CONTACT ALLERGY; RESPIRATORY ALLERGY; LYMPHOCYTES-T; CYTOKINES; IMMUNOREGULATION;

D O I：

10.1016/0009-2797(92)90116-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemicals vary with respect to the nature of allergic reactions which they will elicit preferentially. A wide variety of environmental and industrial chemicals are known to cause allergic contact dermatitis (contact sensitivity). Some of these are able also to induce respiratory allergy. This article reviews the characteristics of immune responses to different classes of chemical allergens and the role which functional subpopulations of T helper (T(H)) cells and their soluble cytokine products play in the induction of allergic sensitization. In addition, new opportunities to identify and classify chemical allergens based upon characterization of divergent allergic responses is discussed.

引用

页码：1 / 10

页数：10

共 41 条

[1] ACTIVATION AND FUNCTIONS OF CD4+ T-CELL SUBSETS [J].