VASOPRESSIN AND VASCULAR REACTIVITY IN THE DEVELOPMENT DOCA HYPERTENSION IN RATS WITH HEREDITARY DIABETES-INSIPIDUS

To examine the role of vasopressin (VP) in DOC [deoxycorticosterone acetate]-salt hypertension, arterial pressure and renal vascular reactivity were studied in control Long-Evans (LE) rats and in Brattleboro rats homozygous for diabetes insipidus (DI rats). Vascular reactivity to norepinephrine, VP and angiotensin II was assessed in isolated kidneys perfused at constant flow. LE rats showed an increase in arterial pressure (AP) which was significant at 2 wk post DOCA and averaged 180 mm Hg at 4 wk. DI rats lacking VP VP showed no rise in AP after DOCA; DI rats given VP and DOCA developed hypertension with a course and magnitude similar to that observed in LE rats. At 6-10 wk post DOCA, renal vascular reactivity to all agents was increased in LE rats and DI rats replaced with VP. Normotensive DI rats lacking VP showed depressed reactivity. Assessment of changes in reactivity at 3 days post DOCA showed that changes preceded the rise in AP. Apparently VP may play a primary role in the pathogenesis of DOCA hypertension, and its mechanisms may involve an induction of increased vascular reactivity.