TIME AND BIOSEQUENCES

被引:29
作者
SACCONE, C [1 ]
LANAVE, C [1 ]
PESOLE, G [1 ]
机构
[1] CNR,CTR STUDIO MITOCONDRI & METAB ENERGET,I-70126 BARI,ITALY
关键词
MOLECULAR EVOLUTION; BASE COMPOSITION; MOLECULAR CLOCK; STOCHASTIC METHODS; MARKOV MODEL;
D O I
10.1007/BF02407350
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this paper we discuss and demonstrate the importance of several factors relative to the relationship between time and evolution of biosequences. In both quantitative and qualitative measurements of the genetic distances, the compositional constraints of the nucleotide sequences play a very important role. We demonstrate that when homologous sequences significantly differ in base composition we get erratic branching order and/or wrong evaluation of the evolutionary rates. We must consider that every gene may have a different evolutionary dynamic along its sequence, generally linked to its functional constraints; this too can seriously affect its clocklike behavior. We report some cases showing how these factors can affect the quantitative measurements of the genetic distances of biosequences.
引用
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页码:154 / 159
页数:6
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