ORGANIZATION AND QUANTITATIVE-ANALYSIS OF KAINATE RECEPTOR SUBUNIT GLUR5-7 IMMUNOREACTIVITY IN MONKEY HIPPOCAMPUS

被引：43

作者：

GOOD, PF

HUNTLEY, GW

ROGERS, SW

HEINEMANN, SF

MORRISON, JH

机构：

[1] CUNY MT SINAI SCH MED, FISHBERG RES CTR NEUROBIOL, NEW YORK, NY 10029 USA

[2] UNIV COLORADO, HLTH SCI CTR, DEPT PHARMACOL, DENVER, CO 80262 USA

[3] SALK INST BIOL STUDIES, MOLEC NEUROBIOL LAB, LA JOLLA, CA 92037 USA

来源：

BRAIN RESEARCH | 1993年 / 624卷 / 1-2期

关键词：

EXCITATORY AMINO ACID; GLUTAMATE RECEPTOR; PRIMATE; CONFOCAL MICROSCOPY; QUANTITATIVE NEUROANATOMY; NEURODEGENERATION;

D O I：

10.1016/0006-8993(93)90102-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A monoclonal antibody specific for GluR5-7 (mAb-4F5) has been used to characterize the distribution of kainate class glutamate receptor subunits in monkey hippocampus. Immunolabeled neurons were present in all subfields of the hippocampus as well as the dentate gyrus and subiculum. Quantitative immunofluorescence analysis by confocal microscopy demonstrated differential levels of immunoreactivity such that the highest intensities were in neurons within CA1 and subiculum as compared with those within CA3 or dentate gyrus. The regional differences in levels of subunit immunoreactivity correlate with the relative vulnerability of hippocampal neurons in several neurodegenerative disorders.

引用

页码：347 / 353

页数：7

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