STRUCTURE-ACTIVITY-RELATIONSHIPS OF DOUBLE-STRAND RGD PEPTIDES AS GPIIB/IIIA RECEPTOR ANTAGONISTS

被引：8

作者：

OJIMA, I ^{[1
]}

DONG, Q ^{[1
]}

EGUCHI, M ^{[1
]}

OH, Y ^{[1
]}

AMANN, CM ^{[1
]}

COLLER, BS ^{[1
]}

机构：

[1] SUNY STONY BROOK,SCH MED,DIV HEMATOL,STONY BROOK,NY 11794

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(00)80374-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of new double-strand RGD peptides are synthesized and their inhibitory activities evaluated for platelet aggregation. Substantial improvement in activity is observed with these novel RGD peptides in comparison with single-strand RGD peptides. The structure-activity relationships of these double-strand RGD peptides are discussed.

引用

页码：1749 / 1754

页数：6

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