HISTOCHEMICAL-DEMONSTRATION OF MEMBRANOUS LOCALIZATION OF ENDOTHELIAL NITRIC-OXIDE SYNTHASE IN ENDOTHELIAL-CELLS OF THE RAT-BRAIN

被引：24

作者：

TOMIMOTO, H

AKIGUCHI, I

WAKITA, H

NAKAMURA, S

KIMURA, J

机构：

[1] Department of Neurology, Faculty of Medicine, Kyoto University, Kyoto

来源：

BRAIN RESEARCH | 1994年 / 667卷 / 01期

关键词：

ENDOTHELIAL NITRIC OXIDE SYNTHASE; NADPH DIAPHORASE; IMMUNOELECTRON MICROSCOPY; ENDOTHELIAL CELL;

D O I：

10.1016/0006-8993(94)91718-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined cellular and subcellular localization of endothelial nitric oxide synthase by using immunoelectron microscopy. The results showed that immunoreaction products were associated with membranous structure, likely the endoplasmic reticulum and cytoplasmic vesicles. These membranous localization of imunoreactivities at electron microscopic level corresponded to the perinuclear granular structures observed by light microscopic immunohistochemistry for endothelial nitric oxide synthase as well as NADPH diaphorase histochemistry.

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页码：107 / 110

页数：4

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