METHOD DEVELOPMENT AND OPTIMIZATION FOR THE DETERMINATION OF RARE-EARTH-METAL IONS BY CAPILLARY ZONE ELECTROPHORESIS

被引：44

作者：

JIMIDAR, M ^{[1
]}

HAMOIR, T ^{[1
]}

DEGEZELLE, W ^{[1
]}

MASSART, DL ^{[1
]}

SOYKENC, S ^{[1
]}

VANDEWINKEL, P ^{[1
]}

机构：

[1] VRIJE UNIV BRUSSELS,INST FARMACEUT,B-1090 BRUSSELS,BELGIUM

来源：

ANALYTICA CHIMICA ACTA | 1993年 / 284卷 / 01期

关键词：

ELECTROPHORESIS; CAPILLARY ZONE ELECTROPHORESIS; CENTRAL COMPOSITE DESIGN; INDIRECT DETECTION; LANTHANIDES; RARE EARTHS;

D O I：

10.1016/0003-2670(93)80027-I

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The separation of rare earth metal ions by capillary zone electrophoresis in the presence of creatinine as UV-absorbing background electrolyte and the complexing agent 2-hydroxyisobutyric acid was investigated. The separation is mainly influenced by the pH of the buffer and the concentration of the complexing agent. Both parameters were used in a central composite design to determine optimal conditions. After modelling of the migration behaviour, the optimal conditions were selected using a multi-criteria approach in which separation coefficient (alpha), sensitivity and analysis time were considered. Finally, the method was validated regarding its detection limit, linearity and reproducibility.

引用

页码：217 / 225

页数：9

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