TRANSIENT LEUKEMIA FOLLOWED BY MEGAKARYOBLASTIC LEUKEMIA IN A CHILD WITH MOSAIC DOWN-SYNDROME

被引：24

作者：

DOYLE, JJ

THORNER, P

POON, A

TANSWELL, K

KAMELREID, S

ZIPURSKY, A

机构：

[1] Division of Hematology/Oncology and Division of Neonatology, Ontario

[2] Department of Pediatrics and Department of Pathology, Ontario

[3] Cancer Cytogenetics and Molecular Oncology, Ontario

[4] University of Toronto, Toronto, ON

来源：

LEUKEMIA & LYMPHOMA | 1995年 / 17卷 / 3-4期

关键词：

DOWN SYNDROME; TRANSIENT LEUKEMIA; MEGAKARYOBLASTIC LEUKEMIA; MOSAICISM;

D O I：

10.3109/10428199509056843

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A case is presented of a child with mosaic Down syndrome, who presented at birth with a transient leukemia and later progressed to megakaryoblastic leukemia. Evidence is presented that both leukemias were of megakaryoblastic lineage and evolved from a trisomic hematopoietic precursor. This case is unique in the poor course of the initial transient neonatal leukemia with improvement following chemotherapy. It also highlights the form of leukemia and associated myelodysplasia that occurs in children with Down syndrome. This form of leukemia and transient leukemia are interrelated and are unique to children with Down syndrome.

引用

页码：345 / 350

页数：6

共 44 条

[1]

Ross J.D., Moloney W.C., Desforges J.F., Ineffective regulation of granulopoiesis masquerading as congenital leukemia in a Mongoloid child, J. Pediatr., 63, pp. 1-10, (1963)

[2]

Honda F., Punnett H.H., Charney E., Miller G., Thiede H.A., Serial cytogenetic and hematologic studies on a mongol with trisomy-21 and acute congenital leukemia, J. Pediatr., 65, pp. 880-887, (1964)

[3]

Engel R.R., Hammond D., Eitzman D.V., Pearson H., Krivit W., Transient congenital leukemia in 7 infants with mongolism, J. Pediatr., 65, pp. 303-305, (1964)

[4]

Wegelius R., Vaananen I., Koskella S.-I., Down's syndrome and transient leukemia-like disease in a newborn, Acta. Pediatr. Scand., 56, pp. 301-306, (1967)

[5]

Nagao T., Lampkin B.C., Hug G., A neonate with Down's syndrome and transient abnormal hematopoiesis: serial blood and bone marrow studies, Blond, 36, pp. 443-447, (1970)

[6]

Clark A.C., Creegan W.J., Stass S.A., Thomas W.J., Schumacher H.R., Pseudoleukemia. Ineffective regulation of granulopoiesis, Arch. Pathol. Lab. Med., 105, pp. 122-125, (1981)

[7]

Zipursky A., Peeters M., Poon A., Megakaryoblastic leukemia and Down's syndrome: a review, Pediatr. Hematol. Oncol., 4, pp. 211-230, (1987)

[8]

Suda J., Eguchi M., Ozawa T., Et al., Platelet peroxidase-positive blast cells in transient myeloproliferative disorder with Down's syndrome, Brit. J. Haematol., 68, pp. 181-187, (1988)

[9]

Hayashi Y., Eguchi M., Sugita K., Et al., Cytogenetic findings and clinical features in acute leukemia and transient myeloproliferative disorder in Down's syndrome, Blood, 72, pp. 15-23, (1988)

[10]

Sartori P.C.E., Darbyshire P.J., Transient myeloproliferative disorder in Down's syndrome: three cases with megakaryocyte markers, Pediatr. Hematol. Oncol., 8, pp. 139-145, (1991)

← 1 2 3 4 5 →