Cultivation of a filamentous mould in an airlift bioreactor

被引：22

作者：

Gavrilescu, M

Roman, RV

机构：

[1] Chemical Pharmaceutical Research Institute Research Centre for Antibiotics, Valea Lupului, Iasi

来源：

ACTA BIOTECHNOLOGICA | 1995年 / 15卷 / 04期

关键词：

D O I：

10.1002/abio.370150402

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cephalosporin C biosynthesis was investigated in a pilot-plant external-loop airlift bioreactor for evaluating the capacity of this bioreactor to surpass the problems which arise from the morphology of the mould and the theology of the broth. Some of the results were compared with those obtained in a stirred tank bioreactor. The dilution and the use of static mixers was necessary to overcome the effects of the high viscosities. The oxygen transfer rate represented 84% of that in the stirred bioreactor, but the efficiency of the power utilization was higher. The specific productivity of Cephalosporin C is comparable to that obtained in the stirred tank bioreactor, but the average specific power consumption was found to be 2/3 Of that in the stirred vessel.

引用

页码：323 / 335

页数：13

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